Saturday, March 30, 2013

HTC One now available on Three UK

Three HTC One

Free HTC One plus unlimited data starting at £34 per month

Right on schedule, we're starting to see broader UK availability for the HTC One, and today Three UK has officially launched the silver version of the handset.

Three's 24-month plans start at £34 per month for its "Ultimate Internet 500" deal, which bags you a free HTC One, unlimited data, 500 minutes and 5,000 texts. For £36 per month you'll get Three's "One Plan," which gets you unlimited data (with tethering included), 2,000 minutes, 5,000 Three-to-Three minutes and 5,000 texts. The phone is also being offered on Pay As You Go for £479.99.

The black HTC One is available for pre-order on the same price plans. More details at the source link.

More: HTC One review

Source: Three UK



Source: http://feedproxy.google.com/~r/androidcentral/~3/syK0Lfj5xUw/story01.htm

stock market stock market Obama Acceptance Speech 2012 dow jones Selena Gomez ariel winter Paige Butcher

Friday, March 29, 2013

Exclusive: Hugh Jackman Digs Into 'The Wolverine' Trailer

'X-Men' actor talks to MTV News exclusively about the new preview.
By Kevin P. Sullivan, with reporting by Josh Horowitz


Hugh Jackman in "The Wolverine"
Photo: Twentieth Century Fox

Source: http://www.mtv.com/news/articles/1704484/the-wolverine-trailer-hugh-jackman.jhtml

Obama Acceptance Speech Prop 30 Election 2012 Michigan Election Results Missouri Election Results Amendment 64 marijuana

Is the U.S. Exporting Coal Pollution?

U.S. coal giants' exports to Europe and Asia are up, and with that global greenhouse gas emissions rise, even if U.S. emissions are falling


coal train A coal train crosses the northern plains near Lethbridge, Alberta. U.S. exports of coal are at an all-time high and could rise higher as domestic utilities switch to natural gas. Experts say the country is simply shipping pollution associated with coal overseas. Image: Flickr/urbanworkbench

LONDON ? The good news is that U.S. greenhouse gas emissions are continuing to decline. "Over the last four years, our emissions of the dangerous carbon pollution that threatens our planet have actually fallen," said President Obama in his State of the Union address last month.

The bad news is the United States is exporting its polluting gases, particularly in the form of coal, like never before.?

Figures released earlier this month by the U.S. Energy Information Administration?show U.S. coal exports reached a record of more than 115 million tons in 2012, more than double the 2009 figure.

In a report examining the legal implications of increased U.S. coal exports, the Columbia Law School notes that greenhouse gas emissions are not just a national issue.

"Because the impacts of CO2 emissions are global in nature, it makes no difference from a climate change perspective whether coal mined in Wyoming is consumed in Chicago or Shanghai," it says.

Higher levels of CO2
Coal is far more polluting in terms of greenhouse gases than either oil or gas, emitting higher levels of CO2 and also other toxic substances such as sulfur dioxide, nitrogen oxide and mercury.

The drop in U.S. emissions ? according to the EIA, total U.S. carbon emissions have now fallen by more than 8 percent since peaking in 2007 ? is in part due to the economic slowdown, but more so to a move from coal-fired electricity generation to less carbon-intensive natural gas, particularly gas produced from hydraulic fracturing or "fracking."

In 2005 coal accounted for half of all electricity generation in the United States: now it generates 37 percent of the country's electricity, with forecasts that figure will drop to around 20 percent by 2030.

The move to gas has been spurred both by tougher regulations on pollution and, with gas production booming, an overall drop in energy prices. There has also been strong growth in renewable energies, particularly in solar power.

Unfazed by domestic decline
U.S. coal giants such as Arch Coal, Alpha Natural Resources and Peabody Energy have not let the decline in domestic demand faze them. Instead they've gone wholesale into export markets, particularly in Europe, with coal-exporting terminals on the U.S. East Coast operating at maximum capacity.

High gas prices within the European Union make U.S. coal extremely competitive as an energy source. Bad weather has contributed to an uptake in demand.

The collapse in price on the EU's European Trading Scheme carbon market and a vast oversupply of so-called pollution permits is another reason for the surge in U.S. coal imports. Worries about energy security and an over-dependence on gas supplies from Russia and the countries of central Asia are additional factors driving the trade.

EIA figures show Europe is now by far the biggest customer for U.S. coal, importing more than all other markets combined. U.S. exports to the UK jumped by about 70 percent in 2012.

Exports to Germany, which phased out nuclear power generation in response to the Fukushima accident in Japan, have also increased.

Europe's energy companies are taking advantage of relatively cheap coal imports while they can. EU regulations, particularly the Large Combustion Plants Directive, stipulate that older coal plants that do not meet stringent emissions targets must be shuttered.

While tighter regulations on pollution could result in a decline in U.S. coal exports to Europe in the years ahead, it's unlikely producers in Pennsylvania or Montana will be cutting back on their activities. Asia, by far the biggest coal-consuming region, where demand continues to grow, is the next target.

Fourth-largest exporter
The United States is the world's fourth largest exporter of coal ? after Australia, Indonesia and Russia. U.S. firms are now setting their sights on the big markets in Asia, particularly China and India.

Source: http://rss.sciam.com/click.phdo?i=af37955013c34dc062a57f6821b3a2a3

yamaguchi road house occupy oakland occupy oakland morgellons disease arik armstead sag awards red carpet

Monday, March 11, 2013

Outpouring follows death of Sportsman Channel host

The Sportsman Channel says it's deeply saddened by the shooting death in northwestern Montana of one of its TV hosts who traveled the world in search of big game and shared his adventures on his program "A Rifleman's Journal."

The company in a statement early Saturday said it will miss Gregory G. Rodriguez's "thoughtfulness, candor and dedication to encourage a safe and enjoyable outdoor experience for all."

Police said Rodriguez, 43, of Sugar Land, Texas, died Thursday in the town of Whitefish when he was shot by another man in an apparent jealous rage while the TV personality visited the shooter's wife.

An outpouring on social media has followed the death of Rodriguez, who combined his comfort in front of the camera and travels to exotic locations with his hunting and shooting expertise into a popular program. The Sportsman Channel said that in January "A Rifleman's Journal" won "Best Instructional/Educational Program" at the Sportsman Channel's Sportsman Choice Awards.

"We're all in a state of shock and disbelief right now," said David Kelly, a spokesman for the Houston Safari Club, of which Rodriguez was a member.

Rodriguez is survived by his wife, Lisa, and two children. In a statement issued Saturday, the family said he was in Montana on a business trip.

"Greg was a wonderful husband, father, son, brother and friend," the statement said. "We love him and will miss him dearly. Please respect the family in their time of mourning and allow them to grieve in peace."

Whitefish Police Chief Bill Dial said that 41-year-old Wayne Bengston shot Rodriguez at about 10:30 p.m. at the home of his wife's mother. Dial said Bengston then beat his wife, took his 2-year-old son to a relative's house and drove to his home about 25 miles away in West Glacier, where he killed himself. Dial said Bengston's wife was treated at a hospital and released that night.

Dial said that Rodriguez and the woman, who works for a firearms manufacturer in the Flathead Valley, met at a trade show and struck up a casual relationship that police do not believe was romantic.

Rodriguez was the founder and CEO of Global Adventure Outfitters. That company declined to comment. According to the company's website, Rodriguez was a mortgage banker before a trip to Africa led him to alter course in the 1990s and start pursuing hunting for a living. He eventually traveled to 21 countries on six continents on that quest, the company said.

___

Ridler reported from Boise, Idaho. Associated Press writer Christopher Sherman contributed to this report from McAllen, Texas.

Source: http://news.yahoo.com/outpouring-follows-death-sportsman-channel-host-193453744.html

kyle orton ncaa tournament schedule black and tan dwight howard trade ncaa bracket 2012 2012 ncaa bracket john carlson

Ohio town mourns 6 teens killed in mysterious car crash

Scott R. Galvin / AP

Mindy Morgan reads a note at the memorial where six teens were killed in a car crash on Park Ave. in Warren, Ohio on March 10.

By Andrew Rafferty, Staff Writer, NBC News

An Ohio town was in mourning on Sunday after a single-car crash took the lives of six teenagers, the deadliest car accident the Buckeye State has seen in three years.

Around 7 a.m. local time, a sport utility vehicle carrying eight people in Warren, Ohio veered to the left, hit a guardrail and flew out of control, according to Ohio State Highway Patrol.? The car came to rest in a pond, and only two of the teens were able to escape and find help.

Killed in the crash were 19-year-old Alexis Cayson, 14-year-old Andrique Bennett, 17-year-old Brandon Murray, and 15-year-olds Kirklan Behner, Daylan Ray, and Ramone White.

All the victims were from Warren, Ohio, about 60 miles east of Cleveland.

Brian Henry, 18, and Asher Lewis, 15, survived and were taken to a local hospital and later released.

Authorities say the Honda Passport was traveling at "highway speeds" when the driver hit the guard rail on?a street where the speed limit is 35 mph. Some of the occupants were wearing seat belts, though it is unclear how many. The SUV only has five seats.

The teens were all friends, but investigators say it is still unclear where they were coming from or going to. At a press conference Sunday night, State Highway Patrol Lt. Brian Holt said, ?none of the occupants of the vehicle had expressed permission to be in possession of the vehicle.? The?car's owner?lives in nearby Youngstown, Ohio, though the automobile had not been reported stolen. Police said it is unclear at this time what the connection is between the vehicle owner and the teens.

Police also declined to speculate on drug use or alcohol pending the results of a toxicology report.

As news spread of crash, mourners throughout the community visited the scene of the accident to grieve. Along with the grief came questions of how it happened and why the victims were out at the early hour.

A local school where several of the teens attended was opened to the community to come for counseling. Counselors will be on hand Monday as well as students return from the weekend.

?It?s going to be a rough week, a rough rest of the school year,? said Michael Notar, Warren school superintendent.?

?

Source: http://usnews.nbcnews.com/_news/2013/03/10/17259173-six-teens-killed-in-ohio-crash?lite

nfl uniforms andrew bailey the village dallas fort worth tornado dallas tornadoes dallas weather nike nfl uniforms

An Interview With Firefighter, Techie, And E-Publisher John Sundman On What It Takes For Creatives To Make It In A Start Up

jrs_simon_signJohn Sundman is best known for his seminal dot-com-boom cyberpunk novel, Acts Of The Apostles but in his long career he has been a truck driver, a fireman, a construction worker, and an early employee at Sun Microsystems. Sundman's cult following has brought him world-wide acclaim. Now, however, he's working at a startup.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/GE7lkw4ZlxA/

carlos condit diaz vs condit super bowl 2012 kickoff time football score ron paul nevada buffalo chicken dip super bowl 2012

Friday, March 8, 2013

Little PSY goes solo after 'Gangnam Style' cameo

In this Wednesday, Dec. 12, 2012 photo. South Korean Hwang Min-woo, the 7-year-old nicknamed "Little PSY," performs during a concert in Seoul, South Korea. Hwang on Wednesday, March. 6, 2013, said that he wanted to gain global fame like his ?big brother,? PSY during his press conference. (AP Photo/Yonhap, Han Jong Chan) KOREA OUT

In this Wednesday, Dec. 12, 2012 photo. South Korean Hwang Min-woo, the 7-year-old nicknamed "Little PSY," performs during a concert in Seoul, South Korea. Hwang on Wednesday, March. 6, 2013, said that he wanted to gain global fame like his ?big brother,? PSY during his press conference. (AP Photo/Yonhap, Han Jong Chan) KOREA OUT

FILE - In this Feb. 25, 2013 file photo, South Korean rapper PSY performs before President Park Geun-hye's presidential inauguration ceremony at the National Assembly in Seoul, South Korea. Sporting a black suit and a sleek haircut, a 7-year-old boy, Hwang Min-woo performed at a news conference in South Korea on Wednesday, March 6, 2013. The impish boy nicknamed ?Little PSY? is releasing an electro pop song next week through iTunes. Min-woo says he wants to gain global fame like his ?big brother,? PSY. (AP Photo/Lee Jin-man, FIle)

(AP) ? The impish boy who showed off his dance moves alongside PSY in "Gangnam Style" is hoping to go viral, too.

The 7-year-old nicknamed "Little PSY" is releasing an electro pop song next week through iTunes. The boy whose real name is Hwang Min-woo says he wants to gain global fame like his "big brother," PSY.

Sporting a black suit and a sleek haircut, Min-woo performed at a news conference in South Korea on Wednesday. He is the latest recruit in the increasingly global K-pop industry.

Min-woo is a second-grader and his mother comes from Vietnam.

Meanwhile, the big PSY has released a "Gangnam Style" remix and is continuing his worldwide tour. The video released on YouTube in July has a record 1.39 billion views.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-03-07-AS-SKorea-People-Little-PSY/id-4a7811792d454a848207ba11e772ae63

did the groundhog see his shadow Ray Lewis Murder UFC 156 my bloody valentine Super Bowl Winners what time does the superbowl start Kaepernick Tattoos

Wednesday, March 6, 2013

Everything You Ever Need to Know About the Periodic Table

The Periodic Table is one of the most iconic—and useful!—pieces of data organization to ever exist. Here's everything you need to know about it, from its history to how to use it, in just 11 minutes. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/G6iWjA3ZD2c/everything-you-ever-need-to-know-about-the-periodic-table

luck sag awards 2012 nominees pro bowl 2012 roster yamaguchi road house occupy oakland occupy oakland

Taliban attack trends: Never mind

FILE - In this Jan. 26, 2012 file photo, an Afghan solider, left, stands guard at the scene of a suicide attack in Lashkar Gah, Helmand province south of Kabul, Afghanistan. The U.S.-led military command in Afghanistan said Tuesday, March 5, 2013 that it will no longer publish figures on Taliban attacks, a week after acknowledging that its report of a 7 percent decline in attacks last year was actually no decline at all. (AP Photo/Abdul Khaleq, File)

FILE - In this Jan. 26, 2012 file photo, an Afghan solider, left, stands guard at the scene of a suicide attack in Lashkar Gah, Helmand province south of Kabul, Afghanistan. The U.S.-led military command in Afghanistan said Tuesday, March 5, 2013 that it will no longer publish figures on Taliban attacks, a week after acknowledging that its report of a 7 percent decline in attacks last year was actually no decline at all. (AP Photo/Abdul Khaleq, File)

(AP) ? The U.S.-led military command in Afghanistan will no longer count and publish the number of Taliban attacks, a statistical measure that it once touted as a gauge of U.S. and allied success but now dismisses as flawed.

The move comes one week after the coalition, known as the International Security Assistance Force, acknowledged in response to inquiries by The Associated Press that it had incorrectly reported a 7 percent drop in Taliban attacks in 2012 compared to 2011. In fact, there was no decline at all, ISAF officials now say.

The mistake, attributed by ISAF officials to a clerical error, called into question the validity of repeated statements by allied officials that the Taliban was in steep decline.

Anthony Cordesman, a close observer of the war as an analyst at the Center for Strategic and International Studies, said it had been clear for months that ISAF's figures were flawed.

"The truth is they should not have published them in the first place," he said. "A great many people realized from the start that it was a meaningless measurement" because it implies that in order to succeed the Taliban has to keep attacking rather than gaining ground by influencing ordinary Afghans. It's that influence which needs to be overcome in order to ensure the viability of the Afghan government.

"Over the last year it has become clearer and clearer that not only was the measurement meaningless, but it became embarrassing because there weren't any (ISAF and Afghan) gains," he added, noting that Taliban attacks last year were more numerous than in 2009, before President Barack Obama sent an extra 30,000 U.S. "surge" troops.

"Basically speaking, we've ended up ? after the surge and three more years of fighting ? with absolutely nothing that we can tell ourselves that shows the level of progress we did or did not achieve," Cordesman said.

The U.S. and its ISAF allies have pledged to end their combat mission by the end of next year, and while they are likely to leave at least several thousand troops to help train Afghan troops, the Afghans are to assume the lead role for security across the entire country this spring, when the Taliban typically step up their attacks.

There are now about 66,000 U.S. troops in Afghanistan.

Statistical measures of battlefield progress have long been a point of dispute, not only in Afghanistan but also in Iraq. The disputes typically are a combination of doubt about the numbers themselves and about what they mean.

Jamie Graybeal, a spokesman for ISAF's headquarters in Kabul, said Tuesday that the coalition has lost confidence in the reporting system that produced its figures on "enemy-initiated" attacks. That is mainly because more combat operations are being performed by Afghan forces, out of view of American and allied troops. That means ISAF has diminishing control over the mechanics of collecting the data.

"We have determined that our databases will become increasingly inaccurate in reflecting the entirety of enemy initiated attacks," Graybeal said in a written statement.

"Additionally, we have come to realize that a simple tally of (attacks) is not the most complete measure of the campaign's progress," he said. "At a time when more than 80 percent of the (attacks) are happening in areas where less than 20 percent of Afghans live, this single facet of the campaign is not particularly accurate in describing the complete effect of the insurgency's violence on the people of Afghanistan."

Taliban insurgents have been pushed out of many population centers and have failed to regain territory they held before the surge of U.S. troops in 2010. But they are expected to test Afghan forces as U.S. and allied troops withdraw.

Coalition officials, including Obama administration officials, had previously cited the reported 2012 drop in Taliban attacks as a sign that the insurgency was in decline and that the Afghans could take on more of the fighting burden.

Last Tuesday, on his final day as defense secretary, Leon Panetta indicated that he was disappointed in the mix-up. The Pentagon on Tuesday said it was leaving it to ISAF to explain the decision to stop reporting attack figures.

Graybeal said ISAF will continue to track Taliban attacks that are observed and recorded by ISAF troops. But it will not track and report on the totality of attacks ? including those directed at Afghan forces.

The erroneous ISAF report of a decline in 2012 attacks came to light after ISAF removed from its website a set of statistics that included its tally of "enemy initiated attacks," which it had said declined by 7 percent. When the AP inquired about the missing figures, ISAF said they had been removed because they contained errors.

Initially, ISAF said it would correct and republish the statistics, but on Tuesday Graybeal said the corrected 2012 figures will not be put back on its web site.

That raises questions about the Pentagon's most recent report to Congress on progress toward stabilizing Afghanistan, which used the coalition's figures on enemy attacks as its main measure of insurgent violence. The report also cautioned in a footnote, however, that the attack figures have "a number of limitations" and should not be used by themselves as a reliable indication of violence levels in Afghanistan.

A Pentagon spokesman, Navy Cmdr. William Speaks, said the issue of counting Taliban attacks will be addressed in the next report to Congress, due by April 30, "and the errors in these figures will be explained." That report will cover developments in Afghanistan from October 2012 through March 2013.

The previous report to Congress, covering the period from April 2012 through September 2012, said ISAF and Afghan forces had continued to "degrade the cohesion and capability" of the insurgency, while acknowledging that the militants were still capable of carrying out high-profile attacks like a stunning assault on Camp Bastion on Sept. 14 in which 15 Taliban fighters breached the security perimeter, killed two U.S. Marines and destroyed six U.S. Marine aircraft.

___

Follow Robert Burns on Twitter at http://www.twitter.com/robertburnsAP

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-03-05-US-Insurgent-Attacks-Error/id-ed926d25faa748d8b5fc857749c2b349

mary j blige burger king islands 2013 nissan altima masters par 3 contest google augmented reality glasses wonderlic test texas tornado

Tuesday, March 5, 2013

HSBC, Standard Chartered to cut bonus payouts on U.S. fines: report

(Reuters) - HSBC and Standard Chartered will report a reduction in their bonus pools, reflecting separate settlements with U.S. authorities over probes into money laundering and sanctions violations, Sky News reported on Sunday.

HSBC's bonus pot will fall to about 2 billion pounds ($3 billion) from 2.8 billion pounds paid out in 2011, Sky News said on its website, with Chief Executive Stuart Gulliver expected to take home 6 million to 7 million pounds, including a bonus of just under 2 million pounds.

His counterpart at Standard Chartered, Peter Sands, will take home less than 2 million pounds in bonus payments, with the bank's overall bonus pool cut to $1.4 billion from $1.54 billion pounds, last year, Sky News said.

In December, HSBC reached a settlement with U.S. authorities and agreed to pay $1.92 billion to settle a probe into laundering money for drug cartels.

In the same month, Standard Chartered agreed to pay $327 million to resolve allegations that it violated U.S. sanctions against Iran, Sudan and two other countries on top of a separate payment the bank made in August last year to New York's state banking regulator over Iran sanctions.

Both companies declined to comment.

(Reporting by Abhishek Takle in Bangalore; Editing by Richard Chang)

Source: http://news.yahoo.com/hsbc-standard-chartered-cut-bonus-payouts-u-fines-215348414--finance.html

arizona immigration law aubrey huff the killers julianne hough brandy michael pineda charles taylor

Study shows mirabegron effective and well tolerated for overactive bladder

Study shows mirabegron effective and well tolerated for overactive bladder [ Back to EurekAlert! ] Public release date: 4-Mar-2013
[ | E-mail | Share Share ]

Contact: Linda Gruner
jumedia@elsevier.com
212-633-3923
Elsevier Health Sciences

New option for patients bothered by antimuscarinic side effects, reported in the Journal of Urology

New York, NY, March 4, 2013 In a new phase III trial mirabegron, a ?3-adrenoceptor agonist, given once daily for 12 weeks, reduced the frequency of incontinence episodes and number of daily urinations, and improved urgency and nocturia in adults with overactive bladder (OAB) compared to those in a placebo group. The incidence of common adverse events (hypertension, urinary tract infection, headache, nasopharyngitis) was similar in the mirabegron and placebo groups in this study. Rates of dry mouth and constipation were similar in the drug and placebo groups. The study is published in the Journal of Urology.

"Mirabegron is a first in class therapeutic agent with a mechanism of action distinct from that of antimuscarinic agents," says urologist Victor W. Nitti, MD, of the NYU Langone Medical Center. "While antimuscarinic agents are the current pharmacological mainstay for OAB, some patients have a suboptimal response or experience side effects such as dry mouth or constipation. The result is that a high proportion of patients on antimuscarinic drugs discontinue therapy, with only 25% remaining on therapy at one year. We need an alternative therapy for some of these patients."

This randomized, parallel group, double-blind phase III study comprising 1329 patients was conducted at 132 sites in the U.S. and Canada. Those eligible for the study voided 8 or more times daily and experienced 3 or more urgency episodes with or without incontinence over a 3-day period. After 2 weeks of receiving placebo, 454 patients were randomized to continue to receive placebo, 442 were given 50 mg mirabegron and 433 received 100 mg mirabegron daily for 12 weeks.

Compared to the placebo group, both mirabegron treatment groups showed statistically significant (p

Urgency and nocturia were reduced in those treated with mirabegron compared to placebo. Significant improvements were seen in quality of life measures, and the magnitude of the treatment response was similar to that seen with other OAB agents.

The frequency of dry mouth was low and similar in all groups. Two percent or fewer of each group reported constipation. No significant differences were noted among the groups for any other treatment-emergent adverse event, including acute urinary retention, cardiac arrhythmia, or hypertension, and there were no significant hematologic or serum chemistry abnormalities.

"With its balanced efficacy, safety, and tolerability profile, mirabegron could provide an alternative therapeutic option for OAB, particularly in patients whose OAB is inadequately addressed by current antimuscarinic therapy," says Dr. Nitti.

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Study shows mirabegron effective and well tolerated for overactive bladder [ Back to EurekAlert! ] Public release date: 4-Mar-2013
[ | E-mail | Share Share ]

Contact: Linda Gruner
jumedia@elsevier.com
212-633-3923
Elsevier Health Sciences

New option for patients bothered by antimuscarinic side effects, reported in the Journal of Urology

New York, NY, March 4, 2013 In a new phase III trial mirabegron, a ?3-adrenoceptor agonist, given once daily for 12 weeks, reduced the frequency of incontinence episodes and number of daily urinations, and improved urgency and nocturia in adults with overactive bladder (OAB) compared to those in a placebo group. The incidence of common adverse events (hypertension, urinary tract infection, headache, nasopharyngitis) was similar in the mirabegron and placebo groups in this study. Rates of dry mouth and constipation were similar in the drug and placebo groups. The study is published in the Journal of Urology.

"Mirabegron is a first in class therapeutic agent with a mechanism of action distinct from that of antimuscarinic agents," says urologist Victor W. Nitti, MD, of the NYU Langone Medical Center. "While antimuscarinic agents are the current pharmacological mainstay for OAB, some patients have a suboptimal response or experience side effects such as dry mouth or constipation. The result is that a high proportion of patients on antimuscarinic drugs discontinue therapy, with only 25% remaining on therapy at one year. We need an alternative therapy for some of these patients."

This randomized, parallel group, double-blind phase III study comprising 1329 patients was conducted at 132 sites in the U.S. and Canada. Those eligible for the study voided 8 or more times daily and experienced 3 or more urgency episodes with or without incontinence over a 3-day period. After 2 weeks of receiving placebo, 454 patients were randomized to continue to receive placebo, 442 were given 50 mg mirabegron and 433 received 100 mg mirabegron daily for 12 weeks.

Compared to the placebo group, both mirabegron treatment groups showed statistically significant (p

Urgency and nocturia were reduced in those treated with mirabegron compared to placebo. Significant improvements were seen in quality of life measures, and the magnitude of the treatment response was similar to that seen with other OAB agents.

The frequency of dry mouth was low and similar in all groups. Two percent or fewer of each group reported constipation. No significant differences were noted among the groups for any other treatment-emergent adverse event, including acute urinary retention, cardiac arrhythmia, or hypertension, and there were no significant hematologic or serum chemistry abnormalities.

"With its balanced efficacy, safety, and tolerability profile, mirabegron could provide an alternative therapeutic option for OAB, particularly in patients whose OAB is inadequately addressed by current antimuscarinic therapy," says Dr. Nitti.

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-03/ehs-ssm030413.php

andrew luck pro day josh johnson kim kardashian flour matt forte jeremy shockey new orleans saints ireland

Banned From Baby Showers: BFBS Changes Priorities

This is personal post. ?I've had moments over the last few weeks that have brought me to a new point. ?I feel compelled to share them with you.

First and foremost, I am a wife (18 years) and mother of 4 children (16, 14, 11, 7). ?I have taught natural childbirth classes for the last 10 years. ?I love what I do. ?It's the best job on the planet!

As you may or may not know, I founded the Tarrant County Birth Network with a couple of amazing ladies over 3 years ago. ?Our leadership grew, as did membership. ?In fact, we grew it to be the largest chapter of BirthNetwork National in the country. ?We put together so many awesome events and meetings. ?I am so proud of all that we accomplished. ?It was a very busy, rewarding time for me personally.

Last January, I agreed to join the BirthNetwork National Board. ?That entailed a lot of phone conversations and emails. ?It took a considerable amount of time, but I had the opportunity to connect with so many women advocating for better birth around the country.

March 24, 2012 we launched Birth Boot Camp childbirth classes. ?I wrote a workbook with the help of Sarah Clark and a few other Birth Boot Camp Board members. We've seen incerdible growth in less than a year. ?We'll do a full report on our anniversary. ?That is not the point of this post.

I cannot begin to tell you what my family has suffered over the last 3 years. Lots of take-out, and fast easy microwaveable meals. ?They've learned to make a few dishes, as a result of me being so busy, like pasta and grilled cheese. ?Even when I'm here, I'm extremely distracted with all that I have to do. ?I'm not really present. ?I'm on the phone or the computer almost non-stop. ?How's this for full-disclosure?

Did I mention that I never talk to my family and close friends anymore - unless they are working on these projects with me, of course! ?I literally haven't had time. ?Those relationships have suffered.

It's like a train moving so fast, you can't get off. ?I could see life going on for my kids and I have barely been a part of it - only the mechanics of getting through the day - just so you can get them to bed and keep working. ?I really love my work. ?Did I mention that?

But I also love my kids. ?Oddly, my relationship with my husband has not suffered. ?He's been?extremely?supportive and my best friend through it all.

A few weeks ago I was on the verge of starting a huge project for BirthNetwork National. ?I had that moment when I stepped back and thought about whether my family could handle another big project, where mom is totally absorbed in something outside the home, even when she is at home? I've nearly got 3 teenagers in the house and they really need me to be more present. ?One is homeschooled, but I haven't had time to take her to do anything extra. ?In fact, my kids haven't been able to?participate?in extracurricular activities because I literally haven't had time to take them. Sad.

I love birth advocacy and working with these women to improve birth, not only locally, but nationally. ? This weekend I've seen so many people I've worked with over the years posting about the CIMS conference and it's been hard to know that I'm not there.

And yet, I am so at peace with my decision. ?I've stepped back from TCBN leadership as well as the BNN Board. ?I've enjoyed my kids over the last few weeks. ?I've made my family dinner! ?I canned beans (I'll tell you how to do it if you really want to know). ?I talked to my mom for over an hour and it was great! ?I chatted with my niece over Facebook this week about a cowboy she's dating (!!!!) and it was so fun. ?I'm totally stalking her page now (shhhh!), whereas I would never have had time for that in previous months. ?It feels so good to reconnect with people I love.

So now I have one job. ?Birth Boot Camp. ?As Founder/President, I have an obligation to our instructors to make this the best company possible. ?Like I mentioned, we are growing so fast because there's nothing else out there like what we're doing. ?I am not pulled between 3 different jobs. ?I have one job and will do it well. It's much easier to set business hours for one job than it is for three!
My family is happier. ?I am happier. I am able to live in the moment, which is something I haven't done in a long time. ?My church calling might actually get the attention it deserves. ?(I'm in charge of SIXTEEN 14-15-year-old girls, which is a huge responsibility and we've got Girls Camp around the corner!) I'm grateful for all that I have and I'm grateful for the realization that it's OK to step away from birth activism for now. ?Between all the kids activities we've recently signed up for, I might even do some long overdue home organization! ?I can't wait!

Source: http://banned-from-baby-showers.blogspot.com/2013/03/bfbs-changes-priorities.html

office max jcp Sports Authority Hollister old navy walmart black friday walmart black friday

Monday, March 4, 2013

PFT: Another big offseasonsl for the?Bucs?

GoodellAP

This week?s flurry of reports regarding quiet curiosity and not-so-quiet interrogation of incoming NFL players on the issue of sexuality represents an obvious symptom of a deeper problem.

Football teams, which notoriously fear the unknown in any shape or form, at best want to know whether there?s a chance that their locker room will be the first one to host an openly gay player.? At worst, one or more football teams possibly don?t want any gay players in the building, openly or closeted.

Although sexual orientation is not yet a protected class under federal law, multiple states shield employees who are gay or suspected to be gay from co-worker hostility or tangible job action (e.g., getting fired, not getting hired, or being passed over for a promotion).

The applicable laws have slightly less meaning in this context, because NFL policy expressly prohibits discrimination on the basis of sexual orientation.

Regardless of the laws or rules that would be broken, for the issue to be teed up in a court of law or in a grievance proceeding under the labor deal or anywhere else, someone has to complain.? The pool of potential plaintiffs consists not of people walking off the street and filling out an application but only of a relatively small group of individuals who already have worked their way through the lower levels of a similar locker-room mentality.

By the time the remaining 330 players or so are being questioned at the Scouting Combine, they?re each the product of the football machine.? And even if they?re troubled by questions about sexuality, what are they going to do about it?

They just want to play football, and to finally get paid for it.? If they?re not among the 256 or so who will get drafted, they?ll want to be among the 2,800 or so who will have a chance to win roster spots or practice-squad assignments after offseason workouts, training camp, and the preseason.

Besides, even if a player believes he has been blackballed based on his actual or perceived sexuality, how will he prove that the decision to cut him was influenced by anything other than his actual or perceived football skills, or lack thereof?? Evidence like inappropriate questions will help, but a player who doesn?t get a job ultimately will have to persuade a jury that he was better at football than someone who did.

The various factors add up to the reality that litigation, which has forced positive change over the past five decades in so many other workplaces, will likely never happen in the NFL.? (If you don?t think litigation effects change, you haven?t noticed the link between the NFL?s effort to protect current players from concussions and the 4,000 or so former players who claim the NFL didn?t do enough to protect them.)

Thus, for change to occur, it will need to come without the expense, annoyance, and worry caused by lawsuits.? And that will require, as Jason Whitlock of FOXSports.com argued earlier this week, real leadership from Commissioner Roger Goodell.

When it comes to the mentality and antics of the locker room, not enough credit is given to the ability of players to change on their own and/or the ability of teams to change them.? The players should be held to a higher standard of conduct and discourse in the locker room, and the teams should be expected to enforce it.

The fact that no gay player in any of the NFL?s 32 workplaces has felt sufficiently comfortable to declare his sexuality means that change hasn?t happened, yet.

Change has happened in countless other workplaces.? Thanks in large part to litigation.? Litigation the NFL most likely will never face on this issue.

The NFL also will likely never face a backlash from its customers for not creating an environment in which closeted gays will feel sufficiently comfortable to come out.? If anything (and based on plenty of the comments posted and emails and tweets we?ve received this week), a team that welcomes an openly gay player could alienate a significant percentage of its fan base.

Thus, the challenge for the league will be to change without a financial incentive to do so.? To change not because it?s the expedient thing to do, but because it?s the right thing to do.

Goodell often explains that his staunch willingness to stand on principle comes from his father?s willingness to sacrifice his position as a U.S. Senator in opposing the Vietnam War.

It?ll be interesting to see whether Goodell, who has been silent to date on the subject, is willing to take a stand on this topic, too.

Source: http://profootballtalk.nbcsports.com/2013/03/03/will-bucs-make-a-splash-in-free-agency/related/

santorum drops out bby zimmerman website miami marlins marlins marlins facebook buys instagram

Friday, March 1, 2013

Pee Diddy? Combs 'fesses up to bed wetting

Ronald Martinez / Getty Images

By Alexis L. Loinaz, E! Online

Blame it on the Kool-Aid.?In a candid mea culpa (or a brilliant case of TMI -- you decide), Sean "Diddy" Combs reveals that as a child, he was prone to a nighttime sleeping habit that led to anything but morning glory.

Yep: The musician was a bed wetter.

Man busted for squatting in Diddy's Hamptons mansion

The 43-year-old came clean about it in an interview with Ellen DeGeneres airing Friday, as Diddy swung by with pal Mark Wahlberg to chat about their partnership to launch a new water brand called AQUAhydrate.

Turns out, it wasn't water but a certain uber-sweet kiddie drink that was the culprit behind his nighttime dilemma.

"One thing I want to say is, I grew up as a Kool-Aid kid," Diddy said, admitting he never drank water. "I used to pour a half a pound of sugar into the Kool-Aid. Besides it having me bouncing off the walls, I used to be a bed wetter."

We'll let that revelation, um, soak for a little bit.

Diddy tweets about "close call" after surviving car crash

"OK, I guess I'm confessing that I used to be a bed wetter," he continued. "So I went on this quest to stop wetting the bed, and the first day that I had a sleepover and I didn't wet the bed, it was, like, one of the greatest days of my life. It gave me the swagger that I have today because I stopped wetting the bed." (So that's the reason behind Diddy's swagger!)

He also had some advice for DeGeneres' young viewers.

"There is something about sugar that makes you wet the bed. So to all you boys and girls out there, as Muhammad Ali used to tell you (to) brush your teeth, I'm telling you to drink water, OK? It will stop you from wetting the bed, and you won't be embarrassed in front of the girls at sleepovers."

Wait -- girls? That was exactly what DeGeneres wondered, to which Diddy replied: "I grew up in the 'hood. Whoever would take the kids, that's who was sleeping over."

Here's hoping everyone was prepared for a change of sheets.

Have you seen The Big Picture? Check out the day's hottest pics

Are you surprised by Sean Combs' revelation? Let us know what you think on Facebook!

Related content:

Source: http://theclicker.today.com/_news/2013/03/01/17146271-sean-combs-too-much-kool-aid-made-me-a-bed-wetter-as-a-child?lite

vincent jackson vicki gunvalson pierre garcon brown recluse spider wiz khalifa taylor allderdice eddie royal iditarod

Dust from Africa affects snowfall in California

By Alicia Chang
AP

LOS ANGELES?? One of the driest spots on Earth ? the Sahara desert ? is increasingly responsible for snow and rain half a world away in the western U.S., a new study released Thursday found.

It's no secret that winds carrying dust, soot and even germs make transcontinental journeys through the upper atmosphere that can affect the weather thousands of miles away. Yet little is known about the impact of foreign pollutants on the West Coast, which relies on mountain snowmelt for its water needs.

Previous studies hinted these jet-setting particles may retard rainfall in the Sierra Nevada mountains in Northern California by reducing the size of water droplets in clouds. But scientists who flew through storm clouds in an aircraft, measured rain and snow and analyzed satellite imagery found the opposite: Far-flung dust and germs can help stimulate precipitation.

During the 2011 winter, a team from the University of California, San Diego and National Oceanic and Atmospheric Administration traced particles suspended in clouds over the Sierra to distant origins ? from the skies over the arid Sahara that later mingled with other pollutants in China and Mongolia before crossing the Pacific.

The days with the most particles in the clouds were also "days when we see the most snow on the ground," said study leader Kimberly Prather, an atmospheric chemistry professor at UC San Diego, whose study was published online Thursday in the journal Science.

Scientists believe wafting dust, grit and microbes ? including bacteria and viruses ? can spur the formation of ice crystals in clouds that in turn can influence how much rain or snow falls.

For years, governments and utilities in California and other Western states have used cloud seeding, in which a chemical vapor is sprayed into clouds, in a bid to increase rainfall.

The new study shows how "Mother Nature has figured out how to give us more precipitation" and that may lead to changes in cloud-seeding efforts, which can be hit-or-miss, Prather said.

David J. Smith at the NASA Kennedy Space Center said it was refreshing to see measurements from the ground, air and orbit to tackle how airborne particles affected Northern California snowfall.

"Such a comprehensive approach is the only way to thoroughly examine global transport" of particles, Smith, who had no role in the research, said in an email.

Online: Science?

Source: http://science.nbcnews.com/_news/2013/02/28/17135604-dust-from-africa-affects-snowfall-in-california?lite

after christmas sales case mccoy case mccoy UFC 155 Jack Klugman merry Christmas a christmas story

Higher Humidity Lowers Flu Transmission

You may be safer from the flu in a humid room than in a dry one, according to a new study from researchers at the Centers for Disease Control and Prevention.

To simulate flu transmission in a health care setting, the researchers used "coughing" and "breathing" mannequins that were placed about 6 feet apart. Flu virus particles were released during a "cough," and devices throughout the room and near each "breathing" mannequin's mouth captured the particles. The particles were then collected and tested for their ability to infect human cells.

At humidity levels of 23 percent, 70 to 77 percent of the flu virus particles were still able to cause an infection an hour after the coughing simulation. But when humidity levels were raised to 43 percent, just 14 percent of the virus particles had the ability to infect. Most of the flu particles became inactive 15 minutes after they were released into the humid air. "The virus just falls apart," at high humidity levels, said study researcher John Noti, of the CDC's National Institute for Occupational Safety and Health.

High humidity was just as detrimental to small flu particles as large ones. That's important because small flu particles tend to hang in the air for a longer time, while large particles fall to the ground, Noti said.

Researchers already knew that humidity levels affect flu transmission . One reason flu transmission is thought to be lower during the summer months is because of the high humidity. But the new study more directly assessed how humidity levels might affect flu transmission in a health care setting, and also took into account flu particle size, said study researcher Donald Beezhold, also of the National Institute for Occupational Safety and Health.

During the summer months, it's pretty easy for indoor humidity levels to be up to 30 to 40 percent, Noti said. But during the winter months it's harder because indoor heating dries out the air, he said. [See Does A Warmer World Mean Less Flu?]

Raising the humidity level of a whole building could be a challenge. But the findings suggest that hospitals might consider raising humidity levels in certain rooms where there might be a high risk for flu transmission, or in rooms with patients who are particularly vulnerable to the flu, such as the intensive care unit (ICU), Noti said.

However, humidity levels should not be too high, because mold starts to grow, Noti said.

The new study is published today (Feb. 27) in the journal PLOS ONE.

Pass it on: The flu virus is less infective at in rooms with higher humidity levels.

Follow Rachael Rettner on Twitter @RachaelRettner, or MyHealthNewsDaily @MyHealth_MHND. We're also on Facebook & Google+.

Copyright 2013 MyHealthNewsDaily, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://news.yahoo.com/higher-humidity-lowers-flu-transmission-235810475.html

weightless ellen degeneres jcpenney yeardley love nba all star reserves rock center christine christine

Emailtor To Release First In Class Hybrid Email Verifier To Public

While there are many substitutions on the rise for email communication, nothing has taken the place of the still powerful email address and how it is used by millions of businesses around the world from email marketing to login systems. At the same time SPAM continues to increase in addition to syntax errors made by a continuous surge of new Internet users.

Various companies and lead building industries, including medical, marketing, and e-commerce systems experience extended support issues when it comes to user email verification and removing invalid emails from their subscriber lists.

While email verification is growing in popularity due to demand, very few solutions have been available to really address the core of the problem and drilling down to mailbox level verification without being banned or limited by Internet Service Providers. Outdated and infective technologies like email verifier software is completely obsolete and never efficiently worked from the start because it relies on a users computer to process email lists. Not to mention the extended amount of time it takes for self-processing.

Other online email verification services have come and gone or never truly deliver to hyped promises of bulk verifying email addresses in real-time. They were unfortunately frauding customers who had high hopes of reducing email bounce and minimizing their email subscribers down to authentic contacts.

Emailtor looks to lead the industry with a history of reputation and service that far exceeds any current offering available to the general public due to a five tier and patented email verification service that will introduce a self-service temporary use format which will keep costs of use down and affordable for hundreds of thousands of companies.

Lane Bryan, operating President and CEO of Emailtor, is the MIT brainchild behind the new private startup after two years of honing a system for large scale enterprise deployment used by many of today's popular email authentication services. "I am extremely happy to see Emailtor finally come online and be ready as a self-service email verifier to individuals and business that rely on email, and are looking to reduce their costs associated with it." said Bryan during a recent convention in Boston.

Emailtor has an email verification API and subscription service in the works to small and medium size businesses that need industry leading strength and affordability in real-time and looking to integrate the Emailtor technology into their own products and services.

To learn more about Emailtor and the coming availability of their online email verifier service, please visit them at http://emailtor.com or contact them at (781) 476-5394 for more information.

About:

Emailtor is an automated system that enables you to clean your email and use our powerful email verification system to reduce your bounce rates. Start today with our email verifier and clean up your email. Emailtor is located in Charlestown, MA and operates their service online with 24 hour availability.

Company Details:

Emailtor

Suite 457, Hood BP 500

Charlestown, MA 02129

Ph: (781) 476-5394

Source: http://www.briefingwire.com/pr/emailtor-to-release-first-in-class-hybrid-email-verifier-to-public

blackout congress censored jerry yang stop sopa justified